| No. | Administrator | Picture | Start of term | End of term | President(s) |
|---|---|---|---|---|---|
| 1 | William D. Ruckelshaus | 1971 | 1973 | Richard Nixon | |
| 2 | Russell E. Train | 1973 | 1977 | Richard Nixon Gerald Ford |
|
| 3 | Douglas M. Costle | 1977 | 1981 | Jimmy Carter | |
| 4 | Anne M. Gorsuch (Burford) | 1981 | 1983 | Ronald Reagan | |
| 5 | William D. Ruckelshaus | 1983 | 1985 | Ronald Reagan | |
| 6 | Lee M. Thomas | 1985 | 1989 | Ronald Reagan | |
| 7 | William K. Reilly | 1989 | 1993 | George H. W. Bush | |
| 8 | Carol M. Browner | 1993 | 2001 | Bill Clinton | |
| 9 | Christine Todd Whitman | 2001 | 2003 | George W. Bush | |
| 10 | Michael O. Leavitt | 2003 | 2005 | George W. Bush | |
| 11 | Stephen L. Johnson | 2005 | 2009 | George W. Bush | |
| 12 | Lisa P. Jackson | 2009 | present | Barack Obama |